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encyclopedia of Rare Disease Annotation for Precision Medicine

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	infective endocarditis

Disease ID	1611
Disease	infective endocarditis
Definition	Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
Synonym	bact endocarditides bact endocarditis bacterial endocarditides bacterial endocarditis bacterial endocarditis (disorder) bacterial endocarditis (disorder) [ambiguous] bacterial endocarditis, nos bacterial infection of the heart valve be - bacterial endocarditis endocarditides bact endocarditides, bacterial endocarditis bact endocarditis, bacterial endocarditis, bacterial [disease/finding] endocarditis, infective nos
DOID	DOID:762 DOID:0060000
UMLS	C0014121
MeSH	D004697
SNOMED-CT	SNOMEDCT_US_2016_09_01:301183007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:89) C0018799 \| heart disease \| 15 C0152021 \| congenital heart disease \| 10 C0018818 \| ventricular septal defect \| 5 C0026267 \| mitral valve prolapse \| 5 C0026266 \| mitral regurgitation \| 5 C0037998 \| splenic infarction \| 5 C0018801 \| heart failure \| 5 C0022658 \| renal disease \| 4 C0035439 \| rheumatic heart disease \| 4 C0017658 \| glomerulonephritis \| 4 C0034065 \| pulmonary embolism \| 3 C0018799 \| cardiac disease \| 3 C0011847 \| diabetes \| 2 C0003504 \| aortic regurgitation \| 2 C0007785 \| cerebral infarction \| 2 C0007102 \| colon cancer \| 2 C0031046 \| pericarditis \| 2 C0035078 \| renal failure \| 2 C0007194 \| obstructive cardiomyopathy \| 2 C0027051 \| myocardial infarction \| 2 C0007785 \| cerebral infarct \| 2 C0007194 \| hypertrophic obstructive cardiomyopathy \| 2 C0014118 \| endocarditis \| 2 C0027051 \| myocardial infarct \| 2 C0155626 \| acute myocardial infarction \| 2 C0042384 \| vasculitis \| 2 C0018802 \| congestive heart failure \| 2 C0272412 \| splenic abscess \| 2 C0031039 \| pericardial effusion \| 1 C0009324 \| ulcerative colitis \| 1 C0917996 \| cerebral aneurysm \| 1 C0040961 \| tricuspid regurgitation \| 1 C0038644 \| sudden infant death \| 1 C0026266 \| mitral incompetence \| 1 C0007222 \| cardiovascular disease \| 1 C1258215 \| ileus \| 1 C0003874 \| septic arthritis \| 1 C0028790 \| cerebral artery occlusion \| 1 C0037998 \| spleen infarct \| 1 C0003486 \| aortic aneurysm \| 1 C0155626 \| acute mi \| 1 C0042373 \| vascular diseases \| 1 C0042373 \| vascular disease \| 1 C0018816 \| septal defects \| 1 C0018818 \| ventricular septal defects \| 1 C0004245 \| av block \| 1 C0042164 \| uveitis \| 1 C1565489 \| renal insufficiency \| 1 C0007766 \| cranial aneurysm \| 1 C0025289 \| meningitis \| 1 C0003504 \| aortic insufficiency \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0013069 \| double outlet right ventricle \| 1 C0034089 \| pulmonary valve stenosis \| 1 C0018824 \| valvular heart disease \| 1 C0011633 \| dermatomyositis \| 1 C0003537 \| aphasia \| 1 C0011849 \| diabetes mellitus \| 1 C0007766 \| intracranial aneurysms \| 1 C0020538 \| hypertension \| 1 C0162871 \| abdominal aortic aneurysm \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0031099 \| periodontitis \| 1 C0022661 \| end-stage renal disease \| 1 C0022116 \| ischaemia \| 1 C0007642 \| cellulitis \| 1 C0267841 \| acalculous cholecystitis \| 1 C0085669 \| acute leukemia \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0019196 \| hepatitis c \| 1 C0028326 \| noonan syndrome \| 1 C0023890 \| liver cirrhosis \| 1 C0023530 \| leucopenia \| 1 C0015230 \| rash \| 1 C0018799 \| heart diseases \| 1 C0409974 \| lupus erythematosus \| 1 C0007222 \| cardiovascular diseases \| 1 C0029443 \| osteomyelitis \| 1 C0043092 \| wegener granulomatosis \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0022660 \| acute renal failure \| 1 C0003864 \| arthritis \| 1 C0018799 \| cardiac diseases \| 1 C0032285 \| pneumonia \| 1 C0004245 \| atrioventricular block \| 1 C0035302 \| retinal artery occlusion \| 1 C0264776 \| tricuspid valve disease \| 1 C0007688 \| central retinal artery occlusion \| 1 C0007766 \| intracranial aneurysm \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:71) 55256 \| ADI1 \| 1.497 \| DISEASES 7917 \| BAG6 \| 1.156 \| DISEASES 913 \| CD1E \| 2.383 \| DISEASES 959 \| CD40LG \| 3.203 \| DISEASES 9308 \| CD83 \| 1.179 \| DISEASES 78987 \| CRELD1 \| 1.164 \| DISEASES 1435 \| CSF1 \| 1.065 \| DISEASES 11330 \| CTRC \| 2.086 \| DISEASES 285440 \| CYP4V2 \| 2.082 \| DISEASES 51071 \| DERA \| 2.086 \| DISEASES 28514 \| DLL1 \| 3.9 \| DISEASES 1755 \| DMBT1 \| 1.186 \| DISEASES 135656 \| DPCR1 \| 2.222 \| DISEASES 1781 \| DYNC1I2 \| 1.417 \| DISEASES 954 \| ENTPD2 \| 1.605 \| DISEASES 3266 \| ERAS \| 2.172 \| DISEASES 2152 \| F3 \| 2.436 \| DISEASES 8928 \| FOXH1 \| 1.765 \| DISEASES 2811 \| GP1BA \| 2.034 \| DISEASES 2993 \| GYPA \| 1.558 \| DISEASES 2994 \| GYPB \| 1.294 \| DISEASES 3106 \| HLA-B \| 1.077 \| DISEASES 3122 \| HLA-DRA \| 1.216 \| DISEASES 81502 \| HM13 \| 1.674 \| DISEASES 3250 \| HPR \| 1.552 \| DISEASES 3329 \| HSPD1 \| 1.946 \| DISEASES 3712 \| IVD \| 2.11 \| DISEASES 23210 \| JMJD6 \| 1.042 \| DISEASES 57158 \| JPH2 \| 1.421 \| DISEASES 84148 \| KAT8 \| 1.395 \| DISEASES 7044 \| LEFTY2 \| 1.724 \| DISEASES 3996 \| LLGL1 \| 1.103 \| DISEASES 9935 \| MAFB \| 1.296 \| DISEASES 4145 \| MATK \| 1.165 \| DISEASES 57591 \| MKL1 \| 4.253 \| DISEASES 51660 \| MPC1 \| 1.797 \| DISEASES 4534 \| MTM1 \| 4.168 \| DISEASES 394263 \| MUC21 \| 2.146 \| DISEASES 23218 \| NBEAL2 \| 1.198 \| DISEASES 4703 \| NEB \| 1.332 \| DISEASES 4879 \| NPPB \| 1.862 \| DISEASES 103752588 \| PACERR \| 2.796 \| DISEASES 5824 \| PEX19 \| 2.358 \| DISEASES 57649 \| PHF12 \| 1.627 \| DISEASES 389072 \| PLEKHM3 \| 2.417 \| DISEASES 5475 \| PPEF1 \| 1.993 \| DISEASES 5530 \| PPP3CA \| 2.24 \| DISEASES 5537 \| PPP6C \| 1.31 \| DISEASES 5783 \| PTPN13 \| 1.33 \| DISEASES 6146 \| RPL22 \| 1.829 \| DISEASES 6164 \| RPL34 \| 1.766 \| DISEASES 23098 \| SARM1 \| 1.507 \| DISEASES 462 \| SERPINC1 \| 2.301 \| DISEASES 871 \| SERPINH1 \| 3.431 \| DISEASES 729238 \| SFTPA2 \| 1.224 \| DISEASES 9467 \| SH3BP5 \| 5.027 \| DISEASES 6539 \| SLC6A12 \| 1.243 \| DISEASES 23583 \| SMUG1 \| 3.228 \| DISEASES 27286 \| SRPX2 \| 1.973 \| DISEASES 10274 \| STAG1 \| 1.526 \| DISEASES 246744 \| STH \| 1.717 \| DISEASES 8801 \| SUCLG2 \| 2.164 \| DISEASES 25870 \| SUMF2 \| 2.996 \| DISEASES 8887 \| TAX1BP1 \| 2.143 \| DISEASES 10732 \| TCFL5 \| 1.06 \| DISEASES 80312 \| TET1 \| 1.626 \| DISEASES 7099 \| TLR4 \| 1.106 \| DISEASES 7124 \| TNF \| 1.727 \| DISEASES 7137 \| TNNI3 \| 2.016 \| DISEASES 7296 \| TXNRD1 \| 1.066 \| DISEASES 23038 \| WDTC1 \| 1.166 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1611
Disease	infective endocarditis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:82) HP:0002617 \| Aneurysmal dilatation \| 23 HP:0001297 \| Cerebral vascular events \| 10 HP:0001634 \| Mitral valve prolapse \| 5 HP:0001653 \| Mitral valve insufficiency \| 5 HP:0000099 \| Glomerular nephritis \| 4 HP:0001629 \| Ventricular septal defects \| 4 HP:0001635 \| Congestive heart failure \| 4 HP:0001659 \| Aortic insufficiency \| 4 HP:0002140 \| Ischemic stroke \| 4 HP:0000083 \| Renal insufficiency \| 3 HP:0002204 \| Pulmonary embolism \| 3 HP:0001945 \| Fever \| 2 HP:0003003 \| Colon cancer \| 2 HP:0001919 \| Acute renal failure \| 2 HP:0030049 \| Brain abscess \| 2 HP:0100584 \| Endocarditis \| 2 HP:0002633 \| Vasculitis \| 2 HP:0001647 \| Bicuspid aortic valve \| 2 HP:0001701 \| Pericarditis \| 2 HP:0001342 \| Intracerebral hemorrhage \| 2 HP:0001631 \| Atria septal defect \| 2 HP:0002170 \| Intracranial hemorrhage \| 2 HP:0000822 \| Hypertension \| 1 HP:0001369 \| Arthritis \| 1 HP:0000554 \| Uveitis \| 1 HP:0100858 \| Celiac artery aneurysm \| 1 HP:0001627 \| Congenital heart defects \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0100859 \| Superior mesenteric artery aneurysm \| 1 HP:0001050 \| Plethora \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0012531 \| Pain \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0011877 \| Increased mean platelet volume \| 1 HP:0011672 \| Cardiac myxoma \| 1 HP:0005180 \| Tricuspid insufficiency \| 1 HP:0002754 \| Bone infection \| 1 HP:0002829 \| Arthralgias \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0001680 \| Coarctation of aorta \| 1 HP:0000979 \| Purpura \| 1 HP:0100806 \| Sepsis \| 1 HP:0004944 \| Cerebral artery aneurysm \| 1 HP:0011934 \| Mesenteric artery aneurysm \| 1 HP:0001287 \| Meningitis \| 1 HP:0006698 \| Ventricular aneurysm \| 1 HP:0001269 \| Hemiparesis \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0001678 \| Atrioventricular block \| 1 HP:0001642 \| Pulmonic stenosis \| 1 HP:0011645 \| Aneurysm of the aortic sinus \| 1 HP:0004942 \| Aortic aneurysm \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0007813 \| Nongranulomatous uveitis \| 1 HP:0001671 \| Abnormality of the cardiac septa \| 1 HP:0002090 \| Pneumonia \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0002381 \| Aphasia \| 1 HP:0004953 \| Abdominal aortic aneurysm \| 1 HP:0001719 \| Double-outlet right ventricle \| 1 HP:0001636 \| Tetrology of fallot \| 1 HP:0011944 \| Small vessel vasculitis \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0100523 \| Hepatic abscess \| 1 HP:0004947 \| Arteriovenous fistula \| 1 HP:0030148 \| Heart murmur \| 1 HP:0006827 \| Degeneration of the spinal cord \| 1 HP:0001643 \| Persistent ductus arteriosus \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0012393 \| Allergy \| 1 HP:0001694 \| Right-to-left shunt \| 1 HP:0000988 \| Exanthem \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0030149 \| Cardiovascular shock \| 1 HP:0100571 \| Cardiac diverticulum \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1

Disease ID	1611
Disease	infective endocarditis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:86) C2707258 \| infections C2598155 \| pain C2364133 \| infection C2072946 \| aortic aneurysm C2004489 \| regurgitation C1963211 \| pericarditis C1963077 \| bone pain C1705714 \| warts C1704212 \| embolism C1621824 \| incomplete atrioventricular block C1550639 \| fistula C1546533 \| abscess C1521999 \| acute myocardial infarction C1455718 \| ventriculitis C1393529 \| vascular complications C1298807 \| acute mitral regurgitation C1282231 \| endogenous endophthalmitis C0948089 \| acute coronary syndrome C0917996 \| cerebral aneurysms C0917996 \| cerebral aneurysm C0865570 \| mitral obstruction C0752303 \| urological manifestations C0752303 \| urological manifestation C0751005 \| intracranial mycotic aneurysm C0577799 \| tricuspid valve vegetation C0549124 \| arterial embolism C0424755 \| fever C0419203 \| osteopathy C0403416 \| crescentic glomerulonephritis C0393851 \| critical illness polyneuropathy C0376293 \| stigmata C0341697 \| renal impairment C0272412 \| splenic abscess C0267842 \| acute acalculous cholecystitis C0264978 \| embolic infarction C0264974 \| superior mesenteric artery aneurysm C0264714 \| acute heart failure C0264693 \| acute coronary insufficiency C0264686 \| coronary embolism C0262469 \| embolic stroke C0240608 \| osler's nodes C0231243 \| early complication C0221239 \| rapidly progressive glomerulonephritis C0151814 \| coronary artery occlusion C0085808 \| mycotic aneurysms C0085808 \| mycotic aneurysm C0042373 \| vascular disease C0040961 \| tricuspid regurgitation C0040961 \| tricuspid incompetence C0039128 \| syphilis C0038454 \| stroke C0038454 \| cerebrovascular accidents C0038454 \| cerebral stroke C0037998 \| splenic infarction C0035085 \| renal infarction C0027697 \| nephritis C0027051 \| myocardial infarction C0026269 \| mitral stenosis C0026267 \| mitral valve prolapse C0026267 \| mitral leaflet prolapse C0026266 \| mitral valve insufficiency C0026266 \| mitral regurgitation C0026266 \| mitral insufficiency C0025289 \| meningitis C0024110 \| lung abscesses C0023885 \| liver abscess C0022658 \| renal diseases C0019080 \| hemorrhage C0018989 \| hemiparesis C0018802 \| congestive heart failure C0018801 \| heart failure C0018799 \| heart disease C0018799 \| cardiac disease C0017658 \| glomerulonephritis C0012628 \| discrete subaortic stenosis C0010051 \| coronary artery aneurysm C0007780 \| cerebral emboli C0007766 \| intracranial aneurysms C0007766 \| intracranial aneurysm C0006105 \| brain abscess C0004610 \| bacteremia C0003504 \| aortic valve regurgitation C0003504 \| aortic regurgitation C0003504 \| aortic incompetence C0002940 \| aneurysms C0002940 \| aneurysm
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:44) C0002940 \| aneurysm \| 17 C0018799 \| heart disease \| 15 C0000833 \| abscess \| 15 C0013922 \| embolism \| 13 C0004610 \| bacteremia \| 11 C0038454 \| stroke \| 10 C0232605 \| regurgitation \| 9 C1393529 \| vascular complications \| 7 C0002940 \| aneurysms \| 6 C0009450 \| infection \| 5 C0085808 \| mycotic aneurysm \| 5 C0026266 \| mitral regurgitation \| 4 C0026267 \| mitral valve prolapse \| 4 C0017658 \| glomerulonephritis \| 4 C0019080 \| hemorrhage \| 4 C0016169 \| fistula \| 4 C0018801 \| heart failure \| 4 C0003504 \| aortic regurgitation \| 3 C0021308 \| infarction \| 3 C0018799 \| cardiac disease \| 3 C0037998 \| splenic infarction \| 3 C0021311 \| infections \| 2 C0007780 \| cerebral emboli \| 2 C0948089 \| acute coronary syndrome \| 2 C0085808 \| mycotic aneurysms \| 2 C0015967 \| fever \| 2 C0006105 \| brain abscess \| 2 C0272412 \| splenic abscess \| 2 C0003486 \| aortic aneurysm \| 1 C0025289 \| meningitis \| 1 C0018802 \| congestive heart failure \| 1 C0031046 \| pericarditis \| 1 C0023885 \| liver abscess \| 1 C0018989 \| hemiparesis \| 1 C0262469 \| embolic stroke \| 1 C0155626 \| acute myocardial infarction \| 1 C0549124 \| arterial embolism \| 1 C0343192 \| microscopic polyangiitis \| 1 C0040961 \| tricuspid regurgitation \| 1 C0264974 \| superior mesenteric artery aneurysm \| 1 C0027051 \| myocardial infarction \| 1 C0030193 \| pain \| 1 C0007766 \| intracranial aneurysm \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1611
Disease	infective endocarditis
Case	(Waiting for update.)

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